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Alpha Brain Clinical Study Results Published in Scientific Journal

March 8, 2018
Updated July 16, 2018
Category: Supplementation

Alpha Brain Clinical Study Shown to Increase Memory, Focus, and Executive Function


When you act illogically, people say you’re on “crazy pills.” When you act foolishly, they ask, “Did you take stupid pills this morning?” But when you’re really on your game, express yourself eloquently, or have a creative stroke of genius, nobody ever accuses you of being on “smart pills.” That’s because, of course, smart pills don’t exist.

Sort of.

Nothing is going to make you into a genius overnight, but what if there really was something you could take that could fire up your brainpower, enhance your ability to store and recall information, and put you into a flow state so that you could do your best work without distraction?

The nootropic Alpha BRAIN is that something, and clinical research shows it.

The Study

In 2016, the results and methodologies from Alpha BRAIN’s clinical trial were accepted and published by the Journal of Human Psychopharmacology: Clinical and Experimental. The study was randomized, double blind, placebo-controlled, and conducted by the Boston Center for Memory. It assigned 63 participants to take either one serving of Alpha BRAIN or a placebo for 45 days. Subjects were evaluated before and after the supplementation period using validated neuropsychological assessments.

The Subjects

“The target demographic we were looking to enroll was exactly who [the product] was being marketed to,” says Todd Solomon, Ph.D., the trial’s director. Specifically, healthy 18 to 35-year-old males and females with above average educations and IQ scores. “More than 50% had a bachelor’s degree or some college,” says Solomon.

The Methods

The subjects were split into two groups. One was given two capsules of Alpha BRAIN (the same recommended dosage Onnit prescribes to customers) while the control received a placebo. Both groups were then put through a battery of different neurocognitive tests. The evaluations looked at different aspects of cognition, from verbal memory to visual memory, short- and long-term memory, executive functioning, processing speed, and attentional tasks.


Alpha Brain Shown to Increase Memory, Focus, and Executive Function

Alpha Brain Clinical Study Results Published in Scientific Journal

“We tried to isolate different areas of cognition,” says Solomon. “The verbal memory tests had to do with being able to remember a list of words after a short and then long delay.” The visual memory tests had the subjects look at shapes and then try to recreate them from memory later on. To test their attention, the men and women were given maze puzzles to solve and arithmetic problems. “These are all well-known, well-validated neuropsychological tasks,” Solomon says.

The Results

There were no noticeable differences in cognitive performance between the two groups at the beginning of the study. After 45 days, both groups showed improvement, but gains in the Alpha BRAIN group were statistically more significant than the placebo.

Specifically, those who took Alpha BRAIN improved their ability to recall a list of words recited to them 20 minutes earlier, thereby boosting their delayed verbal recall. The Alpha BRAIN group also significantly outperformed the placebo group in a test that asks participants to draw a line connecting alternating numbers and letters in sequence as quickly as possible. Faster completion times reflect better executive function, or a set of higher cognitive processes that rely upon attention, memory, inhibition,  and mental flexibility. “The subjects were able to control or parse the information they were getting from the tests better than their counterparts,” says Solomon. “They were less impulsive.”

Onnit CEO Aubrey Marcus commented, “To see our Alpha BRAIN trial published in a major journal is a significant milestone. To know that the results and methodologies of the study were validated through the rigorous peer-review process supports a scientific opinion that we are offering the absolute best nootropic supplement utilizing earth-grown nutrients in existence. Onnit will continue its mission to provide primary, peer-reviewed research on all of its flagship formulas.”

No significant side effects were reported in either study group, and study compliance was high, indicating overall good tolerability with daily Alpha BRAIN use. Furthermore, there were no differences in sleep quality between the two groups.

An abstract of the study with the full study link can be viewed HERE.

What an Alpha Brain Looks Like

In addition to the neuropsychological assessment, a compelling biomarker was added to the study protocol. A subset of the subjects were recruited to participate in electroencephalographic (EEG) brain recording—a measure of brain activity.

The recordings were done at three different times: baseline, one hour after the subjects’ first dose, and after the full 45-day study period. This way, the brain activity from a single dose could be compared to prolonged supplementation.

Remarkably, those taking Alpha BRAIN exhibited statistically faster processing speed and greater response detection amplitudes after both a single dose and at 45 days compared to their placebo counterparts. This data was presented separately and recently published as an abstract in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, available HERE.

Solomon commented, “Having the manuscript of the study accepted in a peer-reviewed journal further validates not only the result of the study, but the scientific rigor that was utilized.”

Onnit’s contribution to the scientific literature sets a precedent for the nutritional supplement industry.

The data has attracted the attention of various researchers with new scopes of study, such as the US Army and the Alzheimer’s Association. Onnit will continue to fund research that is valuable to both consumers of Onnit products and the larger scientific community.


Alpha Brain Clinical Study Results Published in Scientific Journal

Who Can Benefit From Alpha BRAIN?

Most people consume coffee to heighten their focus and alertness, but many can’t handle the side effects. Because Alpha BRAIN is not a stimulant, the jitters and anxiety that often accompany caffeine use don’t apply. If you’ve been looking for something to replace coffee in your morning routine, or at least help you cut back on it, Alpha BRAIN could be your substitute.

And you won’t need nearly as much of it to get the desired effects. While you may require two or more cups of coffee to feel like yourself, the brain scans showed that Alpha BRAIN took effect with a single dose. It’s not habit-forming either.

Since Alpha BRAIN was specifically shown to help subjects recall words, it’s a no brainer that you should take it before studying for any test that has a language component (say, the SAT’s?), and then again before taking the exam. The same goes if you’re giving a speech or a presentation. If you usually find yourself getting tongue-tied (especially in front of large groups of judgmental eyes), Alpha BRAIN can help you find the right words without a lot of pauses and “ums” in between.

If you’re a writer, musician, or other creative type, you know how frustrating it is to get in “the zone” and then have your concentration shattered by some interruption—be it cars outside your window or even your own wandering mind. Alpha BRAIN promotes flow states, so you can buckle your mind down and keep the creative juices flowing until your project is complete.



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Onnit Research Team
The Onnit Research Team is comprised of medical professionals, researchers, and scientists interested in providing data-driven, actionable information.

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