Alpha BRAIN® Research
Alpha BRAIN®, the flagship cognitive enhancing supplement from Onnit Labs, contains a serving of nine natural, well-researched compounds to create an effective and balanced nootropic. Alpha BRAIN® aims to elevate focus and mental clarity to help the brain achieve improved cognitive functioning. The ingredients in Alpha BRAIN® work on three aspects of enhanced cognition: elevating levels of endogenous neurotransmitters, providing stress-management compounds, and promoting long-term neuro-protection.
The human brain is composed of over 10 billion communicating cells, known as neurons, that make over 60 trillion synaptic connections [source]. Neurotransmitters are the chemical messengers that embody the brain's currency of communication. The highly coordinated processes of production and release of these neurotransmitters determine the relative strength or weakness between neighboring neurons. These connections give rise to complex neural circuits, which underlie the apparent phenomena of human cognition.
It is well known that adequate functioning of neurotransmitter synthesis and release is essential to maintain a healthy cognitive state [source]. Self-perceived states, such as attention, mood, focus, and awareness, are highly dependent on the relative levels of neurotransmitter production. Alpha BRAIN® aims to elevate the levels of neurological production of the neurotransmitters by providing an abundance of biological neurotransmitter precursors. Specifically, Huperzia Serrata and aGPC are targeted at increasing acetylcholine function, an essential component for learning and memory [source, source]. L-theanine, a compound isolated from green tea, has been shown to mimic the important inhibitory effects of GABA neurotransmission, creating a calm and focused mental state [source]. L-tyrosine is a key intermediary in the biosynthesis of the neurotransmitters dopamine, epinephrine, and norepinephrine, with documented mood elevating properties [source]. Conveniently combined together in the Alpha BRAIN® formula, these unique nutrients help provide a strong foundation for the body to enhance endogenous production and maintenance of key neurotransmitters.
Prolonged exposure to environmental stress results in a physiological response that can be harmful to overall health and neurological function. Alpha BRAIN® includes a combination of natural stress-management compounds that have been shown to help buffer the brain from stress and provide an overall calming effect. Under the license from Optigenex, Alpha BRAIN® is the only nootropic to include AC-11®, a potent extract from Uncaria tomentosa, a plant found in the Amazon rainforest that has been used for hundreds of years as an alimentary herb. AC-11® has independently been linked to promoting DNA repair following environmental stress and has documented cognitive benefits [source]. Alpha BRAIN® also includes highly concentrated oat straw (Avena sativa), a promoter of neurological wellbeing and rejuvenation, which has been shown to have a positive impact on cognitive performance in healthy subjects [source]. Lastly, Alpha BRAIN® contains phosphatidylserine, a phospholipid cell component known to possess ergogenic properties and promote stress tolerance in high performance athletes [source]. Alpha BRAIN® aims to help us manage our levels of stress while providing the tools to handle demanding situations, allowing the mind to remain clear and focused.
Targeting Neurological Antioxidants
Oxidative stress, also known as free radical damage, has been implicated in a number of age-related conditions [source]. Alpha BRAIN® includes the highest quality anti-oxidative compounds that have been shown to be beneficial to cognitive function. Pterostilbene, a recently discovered compound isolated from blueberries, has been shown to provide neuroprotection against free radicals [source]. Bacopa Monniera has been used for centuries in the traditional Ayurvedic medical system of India to improve memory and longevity, possessing both antioxidant and aptogenic properties [source]. Research on the use of Bacopa has shown significant memory improvements and protection against the deposit of harmful environmental neurotoxic molecules [source]. Finally, the inclusion of vinpocetine, a derivative of the periwinkle plant, promotes blood flow to the brain and possesses potent anti-oxidant properties [source]. These three potent antioxidants are essential to maintaining a healthy, functional nervous system.
Alpha BRAIN® Delivers
The Alpha BRAIN® formula contains highly effective ingredients that are either cutting edge or have historical use. This combination aims to potentiate the best cognitive performance while maintaining mental clarity and providing long-term neurological health benefits. For data from our first pilot study, click here. Full clinical study is ongoing.